Welcome to the University of Pittsburgh Wei Du Research Laboratory
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University of Pittsburgh
Wei Du Hematopoiesis Research Lab
The laboratory of Dr. Wei Du integrates multi-disciplinary approaches spanning molecular biology, DNA damage repair, stem cell biology, in vivo model, to study the underlying mechanisms by which regulate normal and abnormal hematopoiesis, with the special focus on the pathophysiology of hematologic diseases such as bone marrow (BM) failure and leukemia. For our latest news: LinkedIn.
Recent News
May 3, 2024
Two new NIH grants received! More posdoc positions open in the Du lab!
Dr. Du has received two new NIH grants to study leukemia-associated macrophage (LAM), and aging hematopoiesis. We are looking for motivated Postdoctoral Research Fellows/Associates to join the lab. The positions supported by NIH funding are available in the Hematopoiesis Laboratory in the Division of Hematology and Oncology, Departments of Medicine, at University of Pittsburgh, which is one of the nation's top ranked schools in biomedical research. Come join us! Apply here or Send your CV to duw@upmc.edu for consideration.
Dec 06, 2023
Children's Leukemia Research Association (CLRA) funds our research!
CLRA funded us to study a novel strategy of targeting Stem cell-niche interaction for pediatirc leukemia therapy. Read the full story here
Nov 2, 2023
Blood Podcasts our work!
Our article has been featured in Season 6, Episode 18 on Thursday, November 2nd and Listen to the Podcast. here.
June, 2023
Our recent study is published in Blood!
Our recent study entitled "LepR+ niche cell-derived AREG compromises HSC maintenance under conditions of DNA repair deficiency and aging" has been published in Blood. Read the paper here & here .
June, 2023
Du lab welcomes two new members!
Emily Wolff and Anthony Zhu recently joined the lab. Both of them are fresh Pitt gradutes. They will be great additions to the lab to study underying mechanims regulating hematopoiesis and HSC regeneration under stress conditions.
June 15, 2022
Our JCI paper is online now!
Our JCI paper focusing on HSC regeration is now available at JCI. In the study, we identified the paracrine Wnt5a/Prox1 signalign axis as a regulator of HSC regeneration under conditions of injury and aging. Read the paper here.
Nov 1, 2022
Persistent DNA damage and oncogenic stress-induced Trem1 promotes leukemia in mice
In this Haematologica paper, we investigated the role of TREM1 in hematologic malignancies and uncover previously unknown expression and function of TREM1 in malignant stem cells, and identify TREM1 as a driver of leukemogenesis. Read the paper here.