University of Pittsburgh

Wei Du Lab

The laboratory of Dr. Wei Du integrates multi-disciplinary approaches spanning molecular biology, DNA damage repair, stem cell biology, in vivo model, to study the underlying mechanisms by which regulate normal and abnormal hematopoiesis, with the special focus on the pathophysiology of hematologic diseases such as bone marrow (BM) failure and leukemia. For our latest news: LinkedIn.


Recent News

Dec 06, 2023

Children's Leukemia Research Association (CLRA) funds our research!

CLRA funded us to study a novel strategy of targeting Stem cell-niche interaction for pediatirc leukemia therapy.


Nov 2, 2023

Blood Podcasts our work!

Our article has been featured in Season 6, Episode 18 on Thursday, November 2nd and Listen to the Podcast. here.


Nov 2, 2023

After DNA damage, AREG-ular niche it's not!

Read the Commentary here.


June, 2023

Our recent study is published in Blood!

Our recent study entitled "LepR+ niche cell-derived AREG compromises HSC maintenance under conditions of DNA repair deficiency and aging" has been published in Blood. Read the paper here & here .


June, 2023

Du lab welcomes two new members!

Emily Wolff and Anthony Zhu recently joined the lab. Both of them are fresh Pitt gradutes. They will be great additions to the lab to study underying mechanims regulating hematopoiesis and HSC regeneration under stress conditions.


June 15, 2022

Our JCI paper is online now!

Our JCI paper focusing on HSC regeration is now available at JCI. In the study, we identified the paracrine Wnt5a/Prox1 signalign axis as a regulator of HSC regeneration under conditions of injury and aging. Read the paper here.


Nov 1, 2022

Persistent DNA damage and oncogenic stress-induced Trem1 promotes leukemia in mice

In this Haematologica paper, we investigated the role of TREM1 in hematologic malignancies and uncover previously unknown expression and function of TREM1 in malignant stem cells, and identify TREM1 as a driver of leukemogenesis. Read the paper here.