University of Pittsburgh

Wei Du Hematopoiesis Research Lab



LepR+ niche cell-derived AREG compromises hematopoietic stem cell maintenance under conditions of DNA repair deficiency and aging


Blood, Nov, 2023

Hematopoietic stem cell regeneration through paracrine regulation of the Wnt5a-Prox1 signaling axis


JCI, 2022; 132(12): e155914

Quinacrine-CASIN combination overcomes chemoresistance in human acute lymphoid leukemia


Nat Commu, 2021; 12(1): 6936

Mesenchymal PGD2 activates an ILC2-Treg axis to promote proliferation of normal and malignant HSPCs


Leukemia, 2020; 34(11): 3028-3041

A non-myeloablative conditioning approach for long-term engraftment of human and mouse hematopoietic stem cells


Leukemia, 2018; 32(9): 2041-2046

Deletion of Fanca or Fancd2 dysregulates Treg in mice


Blood, 2014; 123(12):1938-47


  1. Li X, Chatla S, Wilson A, Atale N, Lin Q, Du W. “Persistent DNA damage and oncogenic stress-induced Trem1 promotes leukemia in mice" Haematologica. 2022;107(11):2576-2588.
  2. Li X, Lin Q, Chowdhury F, Mazumder MH, Du W. “FANCD2 and HES1 suppress inflammation-induced PPAR to prevent hematopoietic stem cell exhaustion" Br. J Haematol. 2021;192(3):652-663.
  3. Lin Q, Ma Z, Chowdhury F, Mazumder MH, Du W. “Persistent DNA damage-induced NLRP12 improves hematopoietic stem cell function” JCI Insight. 2020;5(10):133365.
  4. Lin Q, Ma Z, Chowdhury F, Mazumder MH, Du W. “Mesenchymal COX2-derived PGD2 activates an immunosuppressive ILC2-Treg axis and promotes leukemic cell proliferation” Leukemia. 2020;34(11):3028-3041.
  5. Liu W, Du W*, Wang L, Shang X, Ryan MA, Marchioni F, et al. “Rational identification of a Cdc42 inhibitor presents a new regimen for long-term hematopoietic stem cell mobilization” Leukemia. 2019;33(3):749-761. *co-first author


  1. Du W, Amarachintha S, Wilson AF, Pang Q. “The immune receptors Trem1 cooperates with diminished DNA damage response to induce preleukemic stem cell expansion” Leukemia. 2017;31(2):423-433.
  2. Li X, Sipple J, Pang Q, Du W. “Salidroside stimulates DNA repair enzyme Parp-1 activity in HSC maintenance” Blood. 2012;119(18):4162-4173.
  3. Du W, Rani R, Sipple J, Schick J, Myer KC, Mehta P, Davies SM, Pang Q. “The FA pathway counteracts oxidative stress through selective protection of antioxidant defense gene promoters” Blood. 2012;119(18):4142-4151.
  4. Du W, Li X, Sipple J, Pang Q. “Overexpression of IL-3R on CD34+CD38- stem cells defines leukemia-initiating cells in FA AML” Blood. 2011;117(16):4243-4252.
  5. Li J, Du W, Pike S, Andreassen PR, Pang Q. “Oxidative-stress specific interaction between FANCD2 and FOXO3a" Blood. 2009;115(80):1545-1548.
  6. Zhou Y*, Du W*, Koretsky T, Bagby GC, Pang Q “TAT-mediated intracellular delivery of NPM-derived peptide induces apoptosis in leukemic cells and suppresses leukemogenesis in mice” Blood. 2008;112(6):2474-2483. *co-first author