University of Pittsburgh

Wei Du Hematopoiesis Research Lab

Featured Publications


LepR+ niche cell-derived AREG compromises hematopoietic stem cell maintenance under conditions of DNA repair deficiency and aging. ¥Corresponding/Senior author. In press.

LepR+ niche cell-derived AREG compromises hematopoietic stem cell maintenance under conditions of DNA repair deficiency and aging


Blood, 2023; 142(18):1529-1542
Hematopoietic stem cell regeneration through paracrine regulation of the Wnt5a-Prox1 signaling axis

Hematopoietic stem cell regeneration through paracrine regulation of the Wnt5a-Prox1 signaling axis


JCI, 2022; 132(12): e155914
Quinacrine-CASIN combination overcomes chemoresistance in human acute lymphoid leukemia

Quinacrine-CASIN combination overcomes chemoresistance in human acute lymphoid leukemia


Nat Commu, 2021; 12(1): 6936
Mesenchymal PGD2 activates an ILC2-Treg axis to promote proliferation of normal and malignant HSPCs.

Mesenchymal PGD2 activates an ILC2-Treg axis to promote proliferation of normal and malignant HSPCs


Leukemia, 2020; 34(11): 3028-3041
A non-myeloablative conditioning approach for long-term engraftment of human and mouse hematopoietic stem cells

A non-myeloablative conditioning approach for long-term engraftment of human and mouse hematopoietic stem cells


Leukemia, 2018; 32(9): 2041-2046
Deletion of Fanca or Fancd2 dysregulates Treg in mice

Deletion of Fanca or Fancd2 dysregulates Treg in mice


Blood, 2014; 123(12):1938-47

Recent Publications

  1. Zhu AZ, Ma Z, Wolff EV, Lee S, Lin Z, Gao ZJ, Du W. “HES1 regulates mesenchymal stromal cell function by suppressing NFATc2-mediated inflammation" Haematologica. In Press.
  2. Zhu AZ, Ma Z, Wolff EV, Lin Z, Gao ZJ, Li X, Du W. "HES1 is required for mouse fetal hematopoiesis" Stem Cell Res Ther. 2024;15(1):235.
  3. Li X, Chatla S, Wilson A, Atale N, Lin Q, Du W. “Persistent DNA damage and oncogenic stress-induced Trem1 promotes leukemia in mice" Haematologica. 2022;107(11):2576-2588.
  4. Li X, Lin Q, Chowdhury F, Mazumder MH, Du W. “FANCD2 and HES1 suppress inflammation-induced PPAR to prevent hematopoietic stem cell exhaustion" Br. J Haematol. 2021;192(3):652-663.
  5. Lin Q, Ma Z, Chowdhury F, Mazumder MH, Du W. “Persistent DNA damage-induced NLRP12 improves hematopoietic stem cell function” JCI Insight. 2020;5(10):133365.
  6. Lin Q, Ma Z, Chowdhury F, Mazumder MH, Du W. “Mesenchymal COX2-derived PGD2 activates an immunosuppressive ILC2-Treg axis and promotes leukemic cell proliferation” Leukemia. 2020;34(11):3028-3041.
  7. Liu W, Du W*, Wang L, Shang X, Ryan MA, Marchioni F, et al. “Rational identification of a Cdc42 inhibitor presents a new regimen for long-term hematopoietic stem cell mobilization” Leukemia. 2019;33(3):749-761. *co-first author

Early Publications


  1. Du W, Amarachintha S, Wilson AF, Pang Q. “The immune receptors Trem1 cooperates with diminished DNA damage response to induce preleukemic stem cell expansion” Leukemia. 2017;31(2):423-433.
  2. Li X, Sipple J, Pang Q, Du W. “Salidroside stimulates DNA repair enzyme Parp-1 activity in HSC maintenance” Blood. 2012;119(18):4162-4173.
  3. Du W, Rani R, Sipple J, Schick J, Myer KC, Mehta P, Davies SM, Pang Q. “The FA pathway counteracts oxidative stress through selective protection of antioxidant defense gene promoters” Blood. 2012;119(18):4142-4151.
  4. Du W, Li X, Sipple J, Pang Q. “Overexpression of IL-3R on CD34+CD38- stem cells defines leukemia-initiating cells in FA AML” Blood. 2011;117(16):4243-4252.
  5. Li J, Du W, Pike S, Andreassen PR, Pang Q. “Oxidative-stress specific interaction between FANCD2 and FOXO3a" Blood. 2009;115(80):1545-1548.
  6. Zhou Y*, Du W*, Koretsky T, Bagby GC, Pang Q “TAT-mediated intracellular delivery of NPM-derived peptide induces apoptosis in leukemic cells and suppresses leukemogenesis in mice” Blood. 2008;112(6):2474-2483. *co-first author