Welcome to the University of Pittsburgh Wei Du Research Laboratory
Lab Photos
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UPMC Hillman Cancer Center
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Research Overview
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Blood Podcast
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University of Pittsburgh
The laboratory of Dr. Wei Du integrates multi-disciplinary approaches spanning molecular biology, DNA damage repair, stem cell biology, in vivo model, to study the underlying mechanisms by which regulate normal and abnormal hematopoiesis, with the special focus on the pathophysiology of hematologic diseases such as bone marrow (BM) failure and leukemia. For our latest news: LinkedIn.
Two Postdoctoral Research Associate positions supported by NIH funding are available in the Hematopoiesis Laboratory in the Division of Hematology and Oncology, Departments of Medicine, at University of Pittsburgh, which is one of the nation's top ranked schools in biomedical research. Come join us! Apply here or Send your CV to duw@upmc.edu for consideration.
CLRA funded us to study a novel strategy of targeting Stem cell-niche interaction for pediatirc leukemia therapy. Read the full story here
Our article has been featured in Season 6, Episode 18 on Thursday, November 2nd and Listen to the Podcast. here.
Our recent study entitled "LepR+ niche cell-derived AREG compromises HSC maintenance under conditions of DNA repair deficiency and aging" has been published in Blood. Read the paper here & here .
Emily Wolff and Anthony Zhu recently joined the lab. Both of them are fresh Pitt gradutes. They will be great additions to the lab to study underying mechanims regulating hematopoiesis and HSC regeneration under stress conditions.
Our JCI paper focusing on HSC regeration is now available at JCI. In the study, we identified the paracrine Wnt5a/Prox1 signalign axis as a regulator of HSC regeneration under conditions of injury and aging. Read the paper here.
In this Haematologica paper, we investigated the role of TREM1 in hematologic malignancies and uncover previously unknown expression and function of TREM1 in malignant stem cells, and identify TREM1 as a driver of leukemogenesis. Read the paper here.